You can connect Python applications to your Autonomous Database instance either with a wallet (mTLS) or without a wallet (TLS).

• Install Python and the python-oracledb Driver
  To connect to Autonomous Database from your Python application, install Python and the python-oracledb driver.
• Connect Python Applications Without a Wallet (TLS)
  Connecting a Python application without a wallet (TLS) provides security for authentication and encryption, and security is enforced using client credentials (by providing a username and password).
• Connect Python Applications with a Wallet (mTLS)
  Connecting a Python application with a wallet (mTLS) provides enhanced security for authentication and encryption, and security is enforced using client credentials (by providing a username and password).